NAD+
LONGEVITY / MITOCHONDRIAL FUNCTIONQuick Specifications
| Vial Size | 1000MG |
|---|---|
| BAC Water | 2ML |
| Amount Per Unit | 5MG PER UNIT |
| Recommended Dose | 50MG TO 150MG (10 TO 30 UNITS) |
| Frequency | 10 UNITS DAILY OR 20-30 UNITS 2X PER WEEK |
| Injection Type | INTRAMUSCULAR |
| Timing | Single Dose Not To Exceed 250mg (50 Units) |
Research Overview
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme present in every cell of the body. While technically a coenzyme rather than a peptide, injectable NAD+ is included here because it participates in the same mitochondrial optimization protocols as peptides like MOTS-c and SS-31. NAD+ is required for the electron transport chain and oxidative phosphorylation — without sufficient NAD+, mitochondria cannot efficiently convert nutrients into ATP. It also participates in over 500 enzymatic reactions and is the substrate required for sirtuin activation (SIRT1–SIRT7, the longevity-linked enzyme family), PARP-mediated DNA repair, and CD38-driven immune signaling. Human studies confirm NAD+ levels decline approximately 50% between ages 40 and 60. Injectable NAD+ bypasses the conversion steps required for oral precursors like NMN and nicotinamide riboside, delivering direct bioavailability. A 2024 meta-analysis in Nature Metabolism confirmed the safety and efficacy profile of direct NAD+ supplementation approaches. For research and educational purposes only.
How It Works
Electron Transport Chain Substrate
NAD+ is the essential coenzyme that accepts electrons in the mitochondrial electron transport chain. Without adequate NAD+, mitochondria cannot efficiently convert nutrients into ATP. Each NAD+ molecule cycles between oxidized (NAD+) and reduced (NADH) forms during energy production.
Sirtuin Activation
NAD+ is the required substrate for sirtuin enzymes (SIRT1–SIRT7) — the longevity-linked enzyme family that regulates cellular aging, DNA repair, inflammation control, and metabolic efficiency. As NAD+ levels decline with age, sirtuin activity drops proportionally.
PARP-Mediated DNA Repair
PARP enzymes, which detect and repair DNA strand breaks, consume large quantities of NAD+ during active repair. This creates a competition between DNA repair and energy production for available NAD+, making NAD+ replenishment particularly important under oxidative stress.
Commonly Studied With
These peptides are frequently researched alongside NAD+: 1000mg due to complementary mechanisms:
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Research references
The following PubMed resources are provided for educational reference. External links open in a new tab.
- Rajman L, et al. (2018). Therapeutic potential of NAD-boosting molecules — Cell Metabolism via PubMed
- Yoshino M, et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women — Science via PubMed
- Gomes AP, et al. (2013). Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication — Cell via PubMed
NAD+: 1000mg information on this page is for research and educational purposes only. This content is not FDA-approved, does not constitute medical advice, and should not be used to guide personal health decisions. Consult a qualified healthcare professional before using any research compound.
Dose Calculator
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Recommended dose: 50MG TO 150MG (10 TO 30 UNITS)