The Journal
Evidence-based research articles on peptide science. Written for researchers, biohackers, clinicians, and science-driven individuals who want depth over simplicity.
The KLOW Stack: GHK-Cu, KPV, BPC-157 and TB-500 Research Guide
The KLOW Stack adds KPV to the proven Glow trio — creating a four-peptide combination that addresses skin regeneration, tissue repair, vascularization, cellular mobilization, and anti-inflammatory signaling through four non-overlapping mechanisms simultaneously.
Read article →Chinese Peptides Explained: What the Research Actually Says
In January 2026, a NYT investigation made "Chinese peptides" a mainstream search term. This article addresses what the evidence actually shows about safety, sourcing, and responsible research.
Read article →VIP Peptide and the MCAS Research Protocol: A Guide
VIP is a 28-amino acid neuropeptide and endogenous immune modulator with targeted VPAC receptor biology. Its ability to reduce pro-inflammatory cytokines by up to 40% without broadly suppressing immune function makes it central to MCAS and CIRS research protocols.
Read article →What Are Research Peptides? A Beginner's Guide for 2026
A plain-language guide to what research peptides are, what the evidence shows, what the regulations are, and how to approach the information responsibly.
Read article →The Nootropic Peptide Stack: Cognitive Research Guide for 2026
Noopept, Semax, Selank, Pinealon, PE-22-28, and the Calm and Clarity blend — mechanisms, cognitive research applications, and principled stacking considerations across multiple brain pathways.
Read article →Peptides for Fat Loss: A Weight Management Research Guide
AOD-9604, GLP-1, GLP-1 Dual Agonist, GLP-3, Survodutide, and Cagrilintide — mechanisms, Phase 3 clinical data, and research protocol considerations across the full weight management peptide class.
Read article →CJC-1295 and Ipamorelin: The Growth Hormone Stack Research Guide
The most studied GHRH and GHRP combination in growth hormone research — receptor biology, why the pairing is synergistic rather than additive, and the full dosing protocol.
Read article →ARA-290 (Cibinetide) — Neuropathic Pain and Autoimmune Research Guide
ARA-290 is a non-hematopoietic EPO analogue with FDA Fast-Track designation for autoimmune small fiber neuropathy — activating the innate repair receptor (IRR) for neuroprotection and anti-inflammatory signaling without red blood cell stimulation.
Read article →The Glow Stack: GHK-Cu, BPC-157, and TB-500 for Skin and Hair Research
GHK-Cu activates approximately 31% of human tissue remodeling genes. Combined with BPC-157's angiogenesis signal and TB-500's anti-fibrotic and cellular mobilization effects, the stack addresses skin aging from three complementary angles.
Read article →Peptide Stacking Guide: How to Combine Peptides for Research
A complete guide to peptide stacking — mechanistic complementarity vs redundancy, the most researched combinations across all major categories, and timing and sequencing considerations.
Read article →P21 Peptide — CNTF-Derived Neurogenesis Research Guide
P21 is a CNTF-derived tetrapeptide that stimulates hippocampal neurogenesis and reduces tau phosphorylation without CNTF's adverse effects. Outperformed Cerebrolysin in comparative Alzheimer's animal studies. Blood-brain barrier penetrant.
Read article →The Khavinsky Longevity Protocol: Epithalon, Thymalin, and Pinealon
Professor Vladimir Khavinsky's bioregulator peptide protocol targeting three primary aging regulatory systems — the pineal gland, thymus, and brain cortex — with 40 years of research behind it.
Read article →SHLP2 and SHLP6 — The Expanding Mitochondrial-Derived Peptide Family
SHLP2 and SHLP6 complete the known mitochondria-encoded peptide family alongside MOTS-c and Humanin. SHLP2 adds cytoprotective and anabolic-sparing properties; SHLP6 shows a unique pro-apoptotic profile in cancer cells while protecting normal cells.
Read article →The Mito Stack: SS-31, MOTS-c, and NAD+ — A Mitochondrial Research Guide
SS-31 repairs the mitochondrial membrane, MOTS-c drives biogenesis, and NAD+ supplies the coenzyme currency both processes require. The most comprehensive mitochondrial research protocol currently available.
Read article →The Gut Healing Stack — Larazotide, KPV, and BPC-157 Research Protocol
The most comprehensive all-oral gut research protocol combining Larazotide for tight junction repair, KPV for mucosal anti-inflammation, and BPC-157 for tissue healing — three complementary mechanisms addressing all layers of gut dysfunction.
Read article →The Wolverine Stack: BPC-157 and TB-500 Research Guide
The most recognized peptide combination in tissue repair research. BPC-157 handles vascularization, TB-500 handles cellular mobilization — distinct mechanisms that together produce a broader repair signal than either alone.
Read article →Triptorelin and the HPG Axis Restart Protocol — Research Guide
Triptorelin is the most studied peptide for HPG axis testosterone restart after TRT or androgen suppression — a long-acting GnRH agonist whose initial LH/FSH flare response is exploited in single-dose (0.1mg) restart protocols.
Read article →The Longevity Master Stack — Epithalon, Thymalin, MOTS-c, and SS-31 Research Protocol
The most comprehensive anti-aging research protocol combining Epithalon (telomere-pineal axis), Thymalin (immune aging), MOTS-c (mitochondrial biogenesis), and SS-31 (membrane repair) — four distinct biological aging mechanisms targeted simultaneously.
Read article →GLP-1 vs GLP-1 Dual Agonist vs GLP-3: Mechanisms, Clinical Data, and Research Implications
The evolution from single GLP-1 receptor agonism to dual GIP/GLP-1 co-agonism and triple GLP-1/GIP/glucagon agonism represents one of the most significant progressions in metabolic medicine research of the past decade.
Read article →How to Reconstitute Peptides: A Step-by-Step Protocol Guide
Proper reconstitution is the foundation of accurate peptide research — errors in this step affect every downstream variable including dosing precision, stability, and sterility.
Read article →BPC-157: A Complete Research Guide
BPC-157 is one of the most extensively studied healing peptides in preclinical research, with over 500 published studies spanning tendon, muscle, gut, cardiovascular, and neurological applications.
Read article →The Mitochondrial-Derived Peptide (MDP) Family — MOTS-c, Humanin, SS-31, and the SHLP Series
A complete research guide to the full family of mitochondria-encoded peptides — MOTS-c, Humanin, SHLP2, SHLP6, and the role of SS-31 in mitochondrial membrane repair — the most comprehensive MDP reference available.
Read article →The Complete MCAS Peptide Research Protocol — VIP, LL-37, KPV, and TA-1
A comprehensive research guide to the four-peptide MCAS protocol — VIP for mast cell degranulation suppression, LL-37 for antimicrobial defense, KPV for mucosal anti-inflammation, and TA-1 for T-regulatory cell normalization.
Read article →The Gut-Brain Axis and Peptides — Larazotide, KPV, BPC-157, and VIP
How research peptides interact with the gut-brain axis — Larazotide for tight junction repair, KPV for mucosal anti-inflammation, BPC-157 for gut tissue healing, and VIP for bidirectional gut-brain neuroimmune signaling.
Read article →Senolytics and Peptides — FOXO4-DRI and the Science of Clearing Senescent Cells
FOXO4-DRI is the most researched peptide senolytic — selectively inducing apoptosis in senescent cells by blocking the FOXO4-p53 interaction. 2025 Nature Communications confirmed the mechanism at atomic resolution.
Read article →FDA Peptide Reclassification 2026 — What the April Policy Shift Means for Researchers
The FDA's April 2026 reclassification of 12 research peptides — including BPC-157's removal from Category 2 — marks the most significant regulatory shift since the 2023 compounding crackdown. What changed, and what it means.
Read article →The Journal is an independent educational publication. All articles are written for research and educational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional.