5-Amino-1MQ
LONGEVITY / MITOCHONDRIAL FUNCTIONQuick Specifications
| Vial Size | 50mg (oral capsules) |
|---|---|
| BAC Water | N/A — oral |
| Amount Per Unit | 50mg per capsule |
| Recommended Dose | 50mg to 100mg (1 to 2 capsules) |
| Frequency | Daily |
| Injection Type | Oral |
| Timing | With or without food |
Research Overview
NNMT (nicotinamide N-methyltransferase) inhibitor. Research suggests support for fat cell metabolism, increased NAD+ availability, and mitochondrial function. Oral administration — no reconstitution required. Research compound only.
How It Works
NNMT Inhibition — Raising NAD+ and SAM
5-Amino-1MQ selectively blocks nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and in doing so consumes SAM (S-adenosylmethionine). NNMT is significantly overexpressed in obese adipose tissue. By inhibiting it, 5-Amino-1MQ raises intracellular NAD+ precursor availability and SAM levels simultaneously — two distinct outcomes with independent downstream effects on fat metabolism.
Pre-Adipocyte Differentiation Blockade
Elevated SAM shifts mesenchymal stem cell fate decisions away from adipogenesis (fat cell formation). SAM is a methyl donor required for the epigenetic changes that drive pre-adipocytes toward mature fat cells. With more SAM available, this differentiation pathway is suppressed, redirecting precursor cells toward muscle and bone lineages instead. Preclinical rodent data shows 7–9% body fat reduction over 8 weeks without caloric restriction or lean mass loss.
Sirtuin Activation and Fat Browning via UCP1
The elevated NAD+ from NNMT inhibition activates SIRT1 and SIRT3 — NAD+-dependent deacetylases that regulate mitochondrial biogenesis and thermogenic gene expression. SIRT1/SIRT3 activation drives upregulation of UCP1 (uncoupling protein 1), the defining marker of thermogenic brown and beige adipocytes. This promotes white adipose tissue browning — converting energy-storing white fat cells into energy-burning beige fat cells — increasing baseline metabolic expenditure without exercise or caloric restriction.
Commonly Studied With
These peptides are frequently researched alongside 5-Amino-1MQ: 50mg oral capsules due to complementary mechanisms:
Research references
The following PubMed resources are provided for educational reference. External links open in a new tab.
- Neelakantan H, et al. (2018). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice — Biochemical Pharmacology via PubMed
- Hong S, et al. (2015). Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization — Nature Medicine via PubMed
- Kraus D, et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity — Nature via PubMed
5-Amino-1MQ: 50mg oral capsules information on this page is for research and educational purposes only. This content is not FDA-approved, does not constitute medical advice, and should not be used to guide personal health decisions. Consult a qualified healthcare professional before using any research compound.
Dose Calculator
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Recommended dose: 50mg to 100mg (1 to 2 capsules)