TB-500
HEALING AND REPAIRQuick Specifications
| Vial Size | 5MG |
|---|---|
| BAC Water | 1ML |
| Amount Per Unit | 0.05MG PER UNIT |
| Recommended Dose | 2.5 TO 5MG (50 TO 100 UNITS) |
| Frequency | TWICE PER WEEK |
| Injection Type | SUBCUTANEOUS |
| Timing | Works in Synergy with BPC-157 |
Research Overview
TB-500 is a synthetic 7-amino acid peptide corresponding to amino acids 17–23 of thymosin beta-4 (Tβ4), a naturally occurring 43-amino acid protein found at high concentrations in blood platelets and wound fluid. Its central mechanism is G-actin sequestration — by binding to monomeric actin, TB-500 regulates cytoskeletal organization and enables rapid cell migration essential for tissue repair. Different segments of the molecule address distinct functions: amino acids 1–4 drive anti-inflammatory and anti-fibrotic effects; amino acids 1–15 contribute to anti-apoptotic properties; amino acids 17–23 handle actin binding, angiogenesis, and dermal wound repair. In preclinical wound models, TB-500 administration increased re-epithelialization by 42% at day 4 and 61% at day 7 compared to controls, with thicker collagen fiber formation and reduced scarring. Research has also explored its cardioprotective effects following cardiac injury, spinal cord neuroprotection, and corneal wound healing. A 2024 study confirmed activation of the Wnt/β-catenin pathway, a primary driver of cell proliferation and tissue homeostasis. TB-500 is frequently studied alongside BPC-157 due to their complementary mechanisms. For research and educational purposes only. Not FDA-approved.
How It Works
G-Actin Sequestration
TB-500's primary mechanism is binding to monomeric (free) actin, keeping it available for rapid cytoskeletal assembly. This enables faster cellular migration into injury sites — a critical bottleneck in tissue healing that determines how quickly repair cells can populate damaged areas.
Anti-Inflammatory & Anti-Fibrotic Action
The N-terminal segment of TB-500 (amino acids 1–4) drives anti-inflammatory and anti-fibrotic effects, reducing scar tissue formation while preserving healthy tissue architecture. This two-pronged action accelerates healing while improving the quality of repaired tissue.
Wnt/β-Catenin Pathway
A 2024 study confirmed TB-500 activates the Wnt/β-catenin signaling pathway — a fundamental cellular mechanism governing cell proliferation, differentiation, and tissue homeostasis — providing a molecular explanation for its broad tissue repair coordination.
Commonly Studied With
These peptides are frequently researched alongside TB-500: 5mg due to complementary mechanisms:
Research references
The following PubMed resources are provided for educational reference. External links open in a new tab.
TB-500: 5mg information on this page is for research and educational purposes only. This content is not FDA-approved, does not constitute medical advice, and should not be used to guide personal health decisions. Consult a qualified healthcare professional before using any research compound.
Dose Calculator
Enter your target dose to calculate the volume to draw.
Recommended dose: 2.5 TO 5MG (50 TO 100 UNITS)