SHLP2
MITOCHONDRIAL FUNCTIONQuick Specifications
| Vial Size | 2MG |
|---|---|
| BAC Water | 2ML |
| Amount Per Unit | 0.01MG PER UNIT |
| Recommended Dose | 50MCG TO 200MCG (5 TO 20 UNITS) |
| Frequency | EVERY OTHER DAY OR 3X PER WEEK |
| Injection Type | SUBCUTANEOUS |
| Timing | Morning SubQ injection. 8-12 week research cycles. Completes the mitochondrial-derived peptide family alongside Humanin, MOTS-c, and SS-31. Benefits are long-term and cellular — expect 4-8 weeks before effects are measurable. Store at -20C before reconstitution; use within 30 days. |
Research Overview
SHLP2 (Small Humanin-Like Peptide 2) is a 20-amino acid mitochondria-encoded peptide discovered in 2016 by researchers at the USC Davis School of Gerontology, encoded within the 12S ribosomal RNA region of the mitochondrial genome — the same genomic locus that encodes Humanin. SHLP2 belongs to the SHLP family (SHLP1-6), all sharing structural homology with Humanin but exerting distinct biological profiles. SHLP2's primary mechanisms include cytoprotection against oxidative stress-induced cell death (analogous to Humanin's protective effect), regulation of anabolic hormone signaling — it modulates IGF-1 responsiveness and improves insulin sensitivity in aging models — and mitochondrial quality maintenance. SHLP2 levels decline measurably with age, paralleling Humanin's age-related decline and suggesting a coordinated mitochondrial aging response. Unlike MOTS-c (which activates AMPK for metabolic reprogramming) and SS-31 (which repairs membrane structural integrity), SHLP2 functions primarily in cellular protection and anabolic signaling preservation — a distinct fourth role in the mitochondrial-derived peptide family. SHLP2 completes the mitochondrial research protocol alongside Humanin (cytoprotection/anti-apoptosis), MOTS-c (metabolic reprogramming), and SS-31 (membrane repair). Research on SHLP2 is earlier-stage than Humanin and MOTS-c but rapidly expanding. For research and educational purposes only.
Commonly Studied With
These peptides are frequently researched alongside SHLP2 (Small Humanin-Like Peptide 2): 2mg due to complementary mechanisms:
For research-grade SHLP2 with third-party Certificate of Analysis documentation, Peptide Hub recommends Apollo Peptide Sciences. Apollo Peptide Sciences carries SHLP2 as part of their mitochondrial research catalog. Affiliate disclosure: we may earn a commission on purchases through this link.
SHLP2 (Small Humanin-Like Peptide 2): 2mg information on this page is for research and educational purposes only. This content is not FDA-approved, does not constitute medical advice, and should not be used to guide personal health decisions. Consult a qualified healthcare professional before using any research compound.
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Recommended dose: 50MCG TO 200MCG (5 TO 20 UNITS)