Dihexa
BRAIN + REPAIRQuick Specifications
| Vial Size | 10MG |
|---|---|
| BAC Water | 1ML |
| Amount Per Unit | 0.1MG PER UNIT |
| Recommended Dose | 10MG TO 40MG |
| Frequency | DAILY OR EVERY OTHER DAY |
| Injection Type | SUBCUTANEOUS OR ORAL |
| Timing | Often dosed orally in community protocols. Cycle length 4-8 weeks. Stack with Semax or BDNF for complementary neuroprotective mechanisms. |
Research Overview
Dihexa (also known as PNB-0408) is a synthetic angiotensin IV-derived heptapeptide studied primarily for its synaptogenic properties — its ability to stimulate the formation of new synaptic connections in the brain. Its researched mechanism involves activation of the hepatocyte growth factor (HGF) / c-Met signaling pathway, which promotes new dendritic spine formation and synaptic plasticity. Important evidence caveat: the foundational 2014 mechanism paper establishing the HGF/c-Met pathway (Benoist et al., Journal of Pharmacology and Experimental Therapeutics) was formally retracted by Washington State University in April 2025 following findings of falsified and fabricated data. This significantly impacts the mechanistic evidence base. The compound remains heavily searched and widely discussed in the research community, and other preclinical work on synaptic enhancement continues, but users and researchers should approach Dihexa with full awareness of this evidence gap. No approved human clinical trials exist. For research and educational purposes only. Note: foundational mechanism paper retracted April 2025 — evidence base is currently limited. Consult a qualified healthcare professional.
Commonly Studied With
These peptides are frequently researched alongside Dihexa: 10mg due to complementary mechanisms:
Dihexa: 10mg information on this page is for research and educational purposes only. This content is not FDA-approved, does not constitute medical advice, and should not be used to guide personal health decisions. Consult a qualified healthcare professional before using any research compound.
Dose Calculator
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Recommended dose: 10MG TO 40MG