BT-11
IMMUNITYQuick Specifications
| Vial Size | 10MG (10 TABLETS x 1MG) |
|---|---|
| BAC Water | N/A — ORAL TABLETS |
| Amount Per Unit | 1MG PER TABLET |
| Recommended Dose | 1MG TO 5MG (1 TO 5 TABLETS) |
| Frequency | DAILY WITH MEALS |
| Injection Type | ORAL TABLETS |
| Timing | Take with food for maximum gut lumen exposure and tolerability. Designed for gut-restricted delivery — engineered not to cross the epithelium. Phase 2 trials used 500mg and 1000mg doses (note: these clinical doses refer to the full capsule formulation including excipients; the active peptide component is the key variable). Pairs with Larazotide (tight junction repair) and KPV (mucosal anti-inflammation) for the gut healing protocol. Can be run continuously or in 4-6 week cycles. |
Research Overview
BT-11 is a gut-restricted, orally bioavailable small molecule peptide ligand developed by Landos Biopharma that selectively activates the LANCL2 (LanC Like Protein 2) signaling pathway in intestinal immune cells. BT-11 is specifically engineered for gut lumen restriction — it does not cross the intestinal epithelium and achieves no meaningful systemic absorption, making it a uniquely targeted gut immune modulator that avoids systemic side effects. LANCL2 is a mammalian homologue of bacterial LanC enzymes that functions as a receptor for abscisic acid (ABA), a plant hormone also produced in human immune cells. LANCL2 activation drives immunoregulatory effects including increased IL-10 production, reduced IL-17 and TNF-alpha secretion, and promotion of T-regulatory cell function in the gut-associated lymphoid tissue (GALT) — recalibrating the hyperactive mucosal immune responses driving IBD and Crohn's disease. Phase 2 clinical trials for Crohn's disease demonstrated favorable safety, reduced fecal calprotectin (an inflammation marker), and symptom improvement. BT-11 addresses mucosal immune dysregulation while Larazotide addresses tight junction structure — the two compounds are mechanistically complementary in gut healing research. Pairs well with the full Gut Healing Stack (Larazotide + KPV + BPC-157 Oral) for multi-mechanism gut barrier restoration. For research and educational purposes only.
Commonly Studied With
These peptides are frequently researched alongside BT-11: 10mg due to complementary mechanisms:
For research-grade BT-11 with third-party Certificate of Analysis documentation, Peptide Hub recommends Apollo Peptide Sciences. Apollo Peptide Sciences carries BT-11 in their gut health research catalog. Affiliate disclosure: we may earn a commission on purchases through this link.
BT-11: 10mg information on this page is for research and educational purposes only. This content is not FDA-approved, does not constitute medical advice, and should not be used to guide personal health decisions. Consult a qualified healthcare professional before using any research compound.
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Recommended dose: 1MG TO 5MG (1 TO 5 TABLETS)