Triple Regulator (TIA-39-C20): 24mg

Weight management

Description

Tia-39-c20 (triple regulator) is a 39-amino acid triple incretin agonist belonging to the peptide receptor modulator research series. it simultaneously activates three receptors: the glp-1 receptor (glp-1r), the gip receptor (gipr), and the glucagon receptor (gcgr). this triple mechanism adds glucagon receptor activation on top of dual incretin agonism — glucagon signaling directly increases resting energy expenditure and hepatic fat oxidation, producing weight loss effects beyond appetite suppression alone. features a c20 fatty diacid (eicosanedioyl) side chain via a γ-glu-2x aeea linker for albumin binding and extended once-weekly half-life. cas: 2381089-83-2. structurally analogous in class to retatrutide. once-weekly subcutaneous injection. key reference literature: jastreboff et al. (nejm 2023) — triple-hormone-receptor agonist phase 2 obesity trial (24.2% weight loss at 48 weeks); sanyal et al. (nature medicine 2024) — retatrutide for masld; rosenstock et al. (lancet 2023) — phase 2 retatrutide vs placebo.

Specifications

Amount in Vial 24mg
BAC Water 2.4ml
Amount per Unit 0.1mg per unit
Recommended Dose titrate up from 2mg to 12mg (20 to 120 units)
Frequency 1x per week
Injection Type Subcutaneous
Timing Same Day Every Week / Starting Dose Is 2 MG — Titrate Very Slowly

Dose Calculator

Based on 0.1mg per unit (100-unit insulin syringe)

Quick Reference

Category Weight management
Dose Range titrate up from 2mg to 12mg (20 to 120 units)
Frequency 1x per week
Route Subcutaneous

Reconstitution

Vial size: 24mg

Add BAC water: 2.4ml

Concentration: 0.1mg per unit

For research and educational use only.

This page provides research dosing information only. Not intended as medical advice. Consult a qualified professional before any use.

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