FOXO4-DRI: 5mg
LongevityDescription
Foxo4-dri (foxo4 d-retro-inverso) is the most researched peptide senolytic — a compound that selectively induces apoptosis in senescent cells by blocking the foxo4-p53 pro-survival interaction. senescent cells are cells that have permanently stopped dividing but remain metabolically active, secreting pro-inflammatory sasp (senescence-associated secretory phenotype) compounds including il-6, tnf-alpha, and matrix metalloproteinases that accelerate aging in surrounding tissue. foxo4-dri disrupts the foxo4-p53 complex specifically in senescent cells (which upregulate foxo4 to resist apoptosis), restoring p53's pro-apoptotic function and triggering selective senescent cell death while leaving healthy cells intact. the landmark 2017 nature paper by baar et al. demonstrated measurable rejuvenation phenotypes in naturally aged mice following treatment. a 2025 nature communications study confirmed the mechanism at atomic resolution. the d-retro-inverso modification uses d-amino acids in reversed sequence, creating resistance to proteolytic degradation and extending half-life. foxo4-dri is studied in longevity protocols alongside epithalon, and senolytics research often pairs it with navitoclax or dasatinib for complementary bcl-2 pathway targeting. for research and educational purposes only.
Specifications
| Amount in Vial | 5mg |
|---|---|
| BAC Water | 2ml |
| Amount per Unit | 0.025mg per unit |
| Recommended Dose | 100mcg to 500mcg (4 to 20 units) |
| Frequency | 3 times per week for 3 weeks (1-2x annually) |
| Injection Type | Subcutaneous |
| Timing | Every other day, 3x/week for 3 weeks per cycle. 1-2 cycles per year. Allow 4-6 weeks post-cycle for cellular clearance effects. Benefits are cumulative and emerge over weeks to months. Commonly studied alongside Epithalon for the longevity-focused protocol. Store at -20C before reconstitution; use within 30 days once reconstituted. |
Dose Calculator
Based on 0.025mg per unit (100-unit insulin syringe)
Quick Reference
Reconstitution
Vial size: 5mg
Add BAC water: 2ml
Concentration: 0.025mg per unit
For research and educational use only.
This page provides research dosing information only. Not intended as medical advice. Consult a qualified professional before any use.